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Puzzling with what genetic variations embeded in cancer cell lines ?
2014-05-21 21:43   发布范围:公开

 

Puzzling with what genetic variations embeded in cancer cell lines ?

Here we introduce a open resource for all your needs here. Besides, the "canSAR" could be more informative if your pay further attention  

 

About canSAR 

canSAR is an integrated knowledge-base that brings together multidisciplinary data across biology, chemistry, pharmacology, structural biology, cellular networks and clinical annotations, and applies machine learning approaches to provide drug-discovery useful predictions.

 

canSAR’s goal is to enable cancer translational research and drug discovery through providing this knowledge to researchers from across different disciplines. It provides a single information portal to answer complex multi-disciplinary questions including - among many others: what is known about a protein, in which cancers is it expressed or mutated and what chemical tools and cell line models can be used to experimentally probe its activity? What is known about a drug, its cellular sensitivity profile and what proteins is it known to bind that may explain unusual bioactivity?

 

Entity Counts

Compounds 1,011,020 unique structures (965,574 free base/acid structures)
3D Structures 100,147
Cell Lines 11,113
Proteins 20,264
Organisms 12,394


Data Counts

Type # Studies # Datapoints
Amplication/Copy Number 746 1,393,956,950
Gene Expression 8,425 (plus data from Array Express) 209,451,071
Chemical Bioactivities 49,912 7,559,760
RNAi 51 177,862


Sources

Name Data Type(s) Last Update / Version
ChEMBL Compounds, Bioactivity Data 02/04/2014 / ChEMBL_18
BindingDB Compounds, Bioactivity Data 26/05/2010
UniProt Proteins 14/05/2014 / 2014_05
PDB 3D Crystal Structures 10/05/2014
STRING Protein to Protein Interaction Data Live via API / Version 8.3
ROCK Protein to Protein Interaction Data Live via API / Version 1.1
Pathway Commons Pathways 23/09/2013 / V4
SCOP Protein Domain Definitions 01/06/2009 / 1.75
Asteroids Protein Domain Definitions 01/10/2009 / 1.75
Array Express Gene Expression Data 21/02/2012
COSMIC Mutations 04/02/2014 / v68


 

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